A Comparative Study on Treatment Efficacy of Zotepine and Quetiapine in Psychotic Patients

Abstract

Zotepine is an antipsychotic used in Japan and Europe for years and recently being introduced in Indian markets. It is claimed to be effective for positive and negative symptoms. Zotepine's primary use is as a treatment for schizophrenia and effective as an antimanic agent in patients with acute bipolar mania. We conducted this study to assess the treatment efficacy of Zotepine Vs Quetiapine in Psychotic patients. It is a randomized, Comparative, Prospective study .The study period is six months that is from July, 2013 to December, 2013. Total study population is 170 subjects. 85 patients were prescribed Zotepine and other 85 patients were prescribed Quetiapine. From this study we conclude that Zotepine has a good treatment efficacy compared to Quetiapine in treatment of psychotic disorders. Sedation was more with Zotepine whereas EPS and weight gain are less when compared to Quetiapine which is statistically significant.