Microwave-Assisted Synthesis of Some Novel Hydrazono-4-Oxothiazolidines as Possible in Vitro Antimicrobial Activity

Abstract

A novel series of Thiazolidin-4-one derivatives were prepared from 2,6-diaryl-3-methyl-piperidin-4-one by microwave irradiation method. All the prepared compounds were characterised by their spectral analysis such as IR, ¹H NMR, ¹³C NMR, Mass spectroscopy and C,H,N analysis.  Also  evaluated for their in vitro antimicrobial activity against three Gram negative strains (Pseudomonas aeruginos, Escherichia coli, Klebsiella pneumoniae), three Gram positive strains (Staphylococcus aureus, Streptococcus faecalis, Bacillus cereus) and fungal strains (Aspergillus flavus, Candida albicans, Penicllium sps, Aspergillus niger, Mucor sps and Rhizopus sps).  The results revealed that all synthesized compounds have a significant biological activity against the tested micro-organisms.