Biological Activities of Some 1, 4-Thiazine-1, 1-Dioxide: Medicinal Chemistry

Abstract

A survey of green synthesis of thiazines revealed the moiety have attracted a great deal of interest of medicinal chemists, biochemist, and pharmacologist and rendered as a lead molecule for designing potential bioactive agents. This review accompanying supplementary green, synthetic information & its references would extend a great deal of help to researchers in determining the best and most productive, economical, suggestive and clinically important compound of thiazine  derivatives which will be expected to show potent pharmacological activities. This has led to the discovery of a wide variety of compounds that are of high interest from the point of view antimicrobial, antimycobacterial, antidiabetic and antidepressant effects among others.  The structural assignments are based on their elemental and spectral data. All the synthesized compounds were preliminarily screened for their in vitro antimicrobial activity against Gram positive organisms (Bacillus subtilis, Staphylococcus aureus) and Gram negative organisms (Escherichia coli and Klebsiella pneumonia) and antifungal activity for Aspergillusniger and Aspergillusfumigatus by disc diffusion method.