Synthesis and Biological Screening of 11-{4'-[(5”-ARYL)-4”-5” DIHYDRO-1”- (H)-PYRAZOL-3”-YL] PHENOXY}-DIBENZO [b,f] THIAZEPINES
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Abstract
11-{4'-[(5''-aryl)-4”-5”dihydro-1”-(H)-pyrazol-3”-yl] phenoxy}-dibenzo [b,f] thiazepines (4a–4j) have been synthesized by the condensation of 11-{4'-[(3”-aryl)- 2”- propene-1”-one]-phenoxy} dibenzo [b,f] thiazepines with hydrazine hydrate.
The constitution of the newly synthesized products have been confirmed by elemental analysis, IR, 1H NMR, Spectroscopy and further supported by mass spectroscopy. The products have been evaluated for their biological activity against gram +ve bacteria, gram –ve bacteria and fungi. Some of the products showed moderate activity compared with known standard drugs.
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How to Cite
Gohel, V. P., & Patolia, V. N. (2014). Synthesis and Biological Screening of 11-{4’-[(5”-ARYL)-4”-5” DIHYDRO-1”- (H)-PYRAZOL-3”-YL] PHENOXY}-DIBENZO [b,f] THIAZEPINES. The International Journal of Science & Technoledge, 2(3). Retrieved from http://internationaljournalcorner.com/index.php/theijst/article/view/138570