Effect of Adedironic Herbal Mixture on Kidney, Electrolyte, Urea and Creatinine of Albino Rats

Abstract

Background

Adedironic mixture is an anti-ulcer herbal mixture used in south western Nigeria as a herbal therapy for peptic ulcers it contains Whole plants of Ageratum conyzoides, roots of Vernonia amygdalina and Citrus aurantifolia and has proven to be a potent herbal therapy for ulcer

Aim and Objective

This study was designed to investigate the effect of Adedironic herbal mixture on the Kidney architecture, Electrolyte, Urea and Creatinine of Albino rats

Materials and Methods

20 rats divided into four groups were used. The control group received 2ml/kg of distilled water while the other three (3) groups were orally administered 0.5, 1.0 and 2.5g/kg/daydoses of Adedironic herbal mixture respectively for 28days. The animals were anesthetized and blood samples were collected for biochemical analysis. The kidneys were harvested and processed for histopathological examination.

Results

Results showed kidney vascular congestion and interstitial nephritis at dose 2.5g/kg and normal histology at dose 0.5g/kg of Adedironic herbal mixture administered. There was significant reduction (p<0.05) in the value of sodium at 0.5g/kgof the concoction, while Potassium, Urea and Creatinine levels were normal when compared with the control group.

Conclusion

With the results of this study it may be concluded that Adedironic herbal mixture has no deleterious effect on the Kidney architecture, Electrolytes, Urea and Creatinine values of albino rats