The Pharmacological Effect of Gum Arabic on Liver Hyperplasia in the Presence or Absence of Laser Beam

Abstract

Background: The pharmacological effect of Gum Arabic with and without laser exposure is largely unknown. Objective: This study aimed to explore the pharmacological effect of GA on hepatic hyperplasia induced by diethylnitrosamine (DENA) in Balb-C mice and the changes in lipid peroxidation, apoptosis and histopathological changes in hepatic hyperplasia mice with or without laser irradiation. Results: In vivo studies showed that GA was biologically inactive expect when combined with laser irradiation in healthy and in hepatic hyperplasia mice, it leds to elevation in lipid peroxidation level. Conclusion:  GA is safe and did not induce biological alterations. Co-administration of GA with laser induced lipid peroxidation.