Synthesis And Biological Activity Of Aniline Derivative Schiff Bases

Abstract

 In the present study new Schiff base compounds derived from amine derivative 1-(2-amino-5-chlorophenyl) -2,2,2, -trifluroethane-1,1-diol hydrochloride with aldehydes such as Isovanillin, Pyridine 2-Carboxyaldehyde , 2-Carboxybenzaldehyde and 3 hydroxy 4 methyl benzaldehyde.  The Schiff base compounds were characterized by IR, and 1H NMR spectroscopy. The Schiff base ligands have also been tested in vitro for their antibacterial and anti fungal activity. The experimental results suggest that Schiff base ligands are more potent in anti bacterial and anti fungal activities.