Synthesis, Characterization and Antiplasmodial Activities of Metal (II) Complexes of Artesuante

Abstract

Metal complexes of Cu (II), Co(II), Ni(II) and Mn(II) were synthesized with the antimalarial drug artesunate as ligand. The complexes were characterized by solubility, melting point, elemental analysis, conductivity measurement, IR and UV-Vis spectroscopy. The results indicated that the complexes possess either tetrahedral or octahedral geometries. The ligand coordinated with metals through the -OH group of the carboxylic functional group. The complexes have been screened for antiplasmodial activities against plasmodial falciparum parasites. The copper (II) complex was found to show higher activity against the parasites than the ligand and the complexes of Co(II), Nickel(II) and Mn(II).