Antimicrobial Screening of Novel Schiff Base Ni (II) Complex Derived From Glutaraldehyde and L-Histidine

Abstract

Transition metal complex of Ni (II) with Schiff base derived from Glutaraldehyde and L-Histidine have been synthesized. Both the ligand and the complex were characterized by magnetic susceptibility, conductance measurement, solubility, elemental analyses, UV-Visible, IR, 1H-NMR spectral studies, powder XRD and TGA. The complex was formed in moderate yield and has sharp melting point. The purity and composition of the Schiff base and the metal (II) complex were established by elemental analysis which metal: ligand ratio of 1:1.The IR spectra revealed that the complex coordinated through azomethine nitrogen and oxygen of the ligand. The magnetic and spectroscopic data indicate an octahedral geometry for the complex. The molar conductance measurement indicates that the complex is non-electrolytic in nature. The electronic absorption spectra of the complex shows intra ligand and charge transfer transitions. Room temperature magnetic susceptibility measurement reveals that the nature of the complex is paramagnetic. The powder XRD data shows that the complex is microcrystalline. Thermal study indicated the stability of the complex. The antimicrobial activities of ligand and its complex were screened by Disc Diffusion method. Metal complex showed better activity against the microbial species than the Schiff base ligand.